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Exerpts from
‘Catalyst’ program ABC TV an interview with Shona
Blair
Shona Blair believes she has discovered
the mechanism of how honey attacks bacteria so effectively.
She’s studied a particularly potent form of
medicinal honey made by bees using Leptospermum, or jelly bush
flowers from Northern NSW and a related plant known as Manuka in New
Zealand.
Shona found that even the notorious Golden Staph is
helpless against the raw power of this honey. Most incredibly,
bacteria don’t seem to become resistant to Leptospermum honey. Shona
tried a different approach to investigating the effects of honey
on bacteria. She looked at the effects on the bacteria’s own
genes, when the bacteria (E. coli) where exposed to
Leptospermum honey. She then looked at which genes where turned on
or off in response to exposure to active honey.
She found
that not only did the medical honey attack the bacteria, it attacked
it on a multi faceted level. More than 100 genes are affected by the
honey, 70 genes increase their activity as if they are trying to
fight an acid attack. 20 genes actually decreased their
activity, disabling the reproductive capacity of the bacteria. It’s
the first time anybody has had any idea on how honey kills
bacteria.
Shona Blair: ‘I looked at all the
different genes. About 70 that were up-regulated, which means they
were turned on more by this honey and about 40 that were
down-regulated so they were actually suppressed by the honey.’
Narration: ‘This is the first time anyone
has been able to show how this honey kills bacteria. The honey was
turning off the genes that allow the bacteria to reproduce. But the
honey also seemed to be activating huge numbers of the bacteria’s
defence genes. It was like nothing Shona had seen before; the
bacteria was acting like it was under attack from a whole range of
assailants from acid, to salt and heat. The honey was overwhelming
the bacteria by attacking it on so many levels at once. ‘
So
rather than one component causing one effect, honey is launching a
multi-pronged attack on the bacteria. And it’s this overwhelming
assault that could explain why bacteria don’t seem to be able to
become resistant to honey.
Shona also mentioned that there’s
been no evidence to show that organisms develop resistance to honey.
In fact they had done experiments trying to the organisma
resistant to the honey and so far this has been
unsuccessful.
Shona Blair ‘The interesting thing
about the honey is it actually seems to stimulate wounds to heal as
well, and no other topical antimicrobial agent does that.’
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